Figure 3.

Mutational analysis of FKS regions

(A) Distribution of the mutations in studied regions of FKS. A non-negligible presence of mutations outside HSs can be observed. Note that Table S5 includes the oligos used for the sequencing. In addition, Data S2 includes the precise mutations.

(B) Distributions of samples according to the presence of mutations in particular FKS gene and distribution of samples according to the presence of mutations in FKS HSs.

(C) Mutational signatures per sequenced regions: FKS1 and FKS2_1 and FKS2_2. Mutated positions are shown as highlighted boxes at the corresponding amino acid in the mutation, over a gray background. Color scale, from white to red, indicates the observed number of mutations (log scale). Darker gray boxes indicate HSs and the white-framed box in FKS2_1 marked positions for other possible mutational HSs. The bottom part of the graph represents an enlargement in HSs and mutations in their close proximity.