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. 2021 Dec 10;161(5):1167–1179. doi: 10.1016/j.chest.2021.11.035

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© 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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A-C, Bar graphs showing exacerbation rates. A, Exacerbation rate declined during the PY from 0.133 exacerbations/person/y to 0.053 exacerbations/person/y (P < .01). B, Exacerbation rates adjusted for ETI therapy and other variables demonstrated no significant difference in the PPY vs PY (0.065 vs 0.054 exacerbations/person/y; P = .68). C, All antibiotic use, including both IV and oral antibiotics, adjusted for ETI therapy and other variables, decreased from 0.612 occurrences/person/y during the PPY to 0.366 occurrences/person/y during in PY (P = .02). ETI = elexacaftor/tezacaftor/ivacaftor; PPY = prepandemic year; PY = pandemic year.