Table 5.
Poisson Mixed Model Explaining Antibiotic Episodes per Year in Adults With CF
| Term | Estimate | SE | z Ratio | P Value |
|---|---|---|---|---|
| Intercept | 0.21 | 0.45 | 0.48 | .63 |
| Quarter of y | –0.10 | 0.05 | –1.92 | .05 |
| Male sex | –0.39 | 0.16 | –2.38 | .02 |
| BMI | 0.01 | 0.01 | 0.52 | .60 |
| Patient is taking ETI | –0.09 | 0.17 | –0.51 | .61 |
| FEV1 % predicted | ||||
| 40-69 | –0.29 | 0.25 | –1.16 | .25 |
| 70-89 | –0.39 | 0.25 | –1.56 | .12 |
| > 90 | –0.74 | 0.30 | –2.48 | .01 |
| During PY | –0.82 | 0.40 | –2.08 | .04 |
| Age group, y | ||||
| 25-34 | 0.07 | 0.21 | 0.33 | .74 |
| 35-44 | –0.26 | 0.26 | –0.99 | .32 |
| 45-54 | –0.54 | 0.30 | –1.78 | .08 |
| 55+ | –0.56 | 0.38 | –1.47 | .14 |
| FEV1 % predicted during PY | ||||
| 40-69 | 0.02 | 0.33 | 0.06 | .95 |
| 70-89 | 0.20 | 0.33 | 0.62 | .54 |
| > 90 | 0.32 | 0.40 | 0.81 | .42 |
| Age group during PY | ||||
| 25-34 | 0.05 | 0.28 | 0.19 | .85 |
| 35-44 | –0.14 | 0.39 | –0.36 | .72 |
| 45-54 | 0.48 | 0.41 | 1.18 | .24 |
| 55+ | 0.47 | 0.49 | 0.95 | .34 |
Poisson mixed model explaining the number of antibiotic episodes per person per year adjusted for time, sex, BMI, and ETI use, year, lung function cohort, age group, and the interaction between lung function cohort and year and between age group and year. A random slope over time was included for each participant. After adjusting for ETI use and other variables, use of antibiotics decreased from 0.612/person/y during the PPY to 0.366/person/y during the PY (z = 2.31; P = .02). CF = cystic fibrosis; ETI = elexacaftor/tezacaftor/ivacaftor; PY = pandemic year.