TABLE 4.

Times to first detection of HCMV in blood following transplantation and to first disappearance of HCMV from blood following onset of antiviral treatment according to different viral assays

Assay for detection of:	Time to first HCMV detection		Time lag by which IE mRNA detection precedes positivity by other assaysa		Time to first HCMV disappearance during therapy
	Mean ± SD days	Pb	Mean ± SD days	Pc	Mean ± SD days	Pd
IE mRNA	37.7 ± 15.4	NAe	NA	NA	7.7 ± 9.8	NA
Antigenemia	39.6 ± 15.6	NSf	5.7 ± 7.7	NS	8.9 ± 10.5	NS
DNAemia	40.9 ± 15.2	NS	4.2 ± 7.4	NS	8.9 ± 10.1	NS
Viremia	43.7 ± 16.3	<0.0005	8.4 ± 8.8	NS	1.6 ± 2.5	<0.01
pp67 mRNA	43.7 ± 17.5	<0.005	6.7 ± 5.6	NS	4.9 ± 8.9	NS

^aDetermined upon first HCMV appearance as well as relapse episodes. 

^bt test. A significant difference was also found for the assay for DNAemia versus the assay for viremia (P < 0.005) and the NASBA for pp67 mRNA (P < 0.05). 

^cKolmogorov-Smirnov test. 

^dKolmogorov-Smirnov test. A significant difference was also found for the assay for DNAemia versus the assay for viremia (P < 0.0001) and the NASBA for pp67 mRNA (P < 0.005) and for the assay for antigenemia versus the assay for viremia (P < 0.01). 

^eNA, not applicable. 

^fNS, not significant.