FIGURE 1.

Elevated oxidative stress in cortical neurons after chemotherapy. (Left) Cancer patients treated with chemotherapy have a higher nitrotyrosine H-score in frontal lobe cortical neurons (48.8) compared to cancer patients not treated with chemotherapy (19.3, p < 0.05) and patients without history of cancer (26.3, p < 0.05). Error bars represent the standard error of the mean. (Right) Representative nitrotyrosine immunostain images from all 3 cohorts counterstained with hematoxylin (400×), *p < 0.05.