Table 1.

Characteristics of the SNPs predicting liability to periodontitis selected as instrumental variables for the Mendelian randomization analysis in Europeans and East Asians.

Population	SNP	locus	Gene	Effect allele	Non effect allele	Effect allele frequency	Beta	Standard error	Odds ratio	95% confidence interval
European	rs1537415	9q34.3	GLT6D1	C	G	0.41	0.4637	0.0797	1.59	(1.36, 1.86)
	rs4284742	19q13.41	SIGLEC5	G	A	0.76	0.2927	0.0521	1.34	(1.21, 1.48)
	rs2738058	8p23.1	DEFA1A3	T	C	0.43	0.2469	0.0415	1.28	(1.18, 1.39)
	rs16870060	8q22.3	MTND1P5	G	T	0.91	0.3075	0.0513	1.36	(1.23, 1.50)
	rs729876	16p13.12	LOC107984137	T	C	0.82	0.2151	0.0384	1.24	(1.15, 1.34)
East Asians	rs10737249	1	COLGALT2	C	T	0.91	0.2329	0.0457
	rs192911809	12	SRRM4	A	G	0.01	1.2330	0.2525
	rs117963472	18	RP11-161I6.2	G	A	0.02	0.4169	0.0903
	rs118016840	21	DSCR8	G	C	0.01	0.6304	0.1247
	rs9812091	3	CLSTN2	G	A	0.45	0.1218	0.0252
	rs7756559	6	RP1-153P14.7	T	C	0.01	0.5933	0.1281
	rs35067614	7	NECAP1P1	G	T	0.18	-0.1622	0.0333