TABLE 2.
Mendelian randomization estimates for liability to periodontitis on HbA1C, fasting glucose and fasting insulin, and T2DM using all five or four SNPs to predict periodontitis obtained from Europeans for the MR estimates in Europeans and seven SNPs to predict periodontitis in East Asians for the MR estimates in East Asians.
| Outcome | Data source | Method | #SNPs | Beta | 95% confidence interval | p-value | Cochran’s Q-statistic (p-value) | MR-Egger | |
|---|---|---|---|---|---|---|---|---|---|
| Intercept p-value | I 2 | ||||||||
| HbA1C (effect size) | United Kingdom Biobank | IVW | 5 | −0.001 | −0.008 to 0.006 | 0.74 | 1.38 (0.85) | 0% | |
| 4 | 0.001 | −0.010 to 0.011 | 0.91 | 1.17 (0.76) | 0% | ||||
| WM | 5 | −0.003 | −0.011 to 0.006 | 0.56 | |||||
| 4 | −0.002 | −0.014 to 0.011 | 0.81 | ||||||
| MRE | 5 | −0.007 | −0.032 to 0.018 | 0.58 | 1.14 (0.77) | 0.63 | 71.0% | ||
| 4 | −0.006 | −0.089 to 0.077 | 0.89 | 1.14 (0.56) | 0.88 | 14.9% | |||
| MAGIC | IVW | 7 | −0.007 | −0.024 to 0.010 | 0.45 | 7.65 (0.26) | 21.6% | ||
| East Asians | WM | 7 | −0.014 | −0.033 to 0.006 | 0.18 | ||||
| MRE | 7 | −0.018 | −0.047 to 0.012 | 0.24 | 6.55 (0.35) | 0.36 | 0% | ||
| Fasting glucose (mmol/L) | MAGIC | IVW | 5 | −0.001 | −0.007 to 0.005 | 0.74 | 1.81 (0.77) | 0% | |
| Europeans | 4 | −0.003 | −0.011 to 0.006 | 0.55 | 1.55 (0.67) | 0% | |||
| WM | 5 | 0.0004 | −0.007 to 0.007 | 0.91 | |||||
| 4 | −0.002 | −0.013 to 0.008 | 0.71 | ||||||
| MRE | 5 | −0.001 | −0.021to 0.020 | 0.96 | 1.81 (0.62) | 0.97 | 71.4% | ||
| 4 | −0.043 | -0.112 to 0.025 | 0.22 | 0.19 (0.91) | 0.24 | 16.7% | |||
| MAGIC | IVW | 7 | 0.023 | −0.005 to 0.051 | 0.11 | 9.39 (0.15) | 36.1 | ||
| East Asians | WM | 7 | 0.018 | −0.013 to 0.050 | 0.26 | ||||
| MRE | 7 | 0.037 | −0.013 to 0.087 | 0.15 | 8.57 (0.13) | 0.49 | 0% | ||
| Fasting insulin (pmol/L) | MAGIC | IVW | 5 | −0.002 | −0.010 to 0.006 | 0.62 | 5.3 (0.26) | 23.8% | |
| Europeans | 4 | −0.008 | −0.018 to 0.002 | 0.12 | 2.8 (0.43) | 0% | |||
| WM | 5 | 0.002 | −0.006 to 0.010 | 0.66 | |||||
| 4 | −0.006 | −0.019 to 0.007 | 0.34 | ||||||
| MRE | 5 | 0.013 | −0.012 to 0.037 | 0.31 | 3.5 (0.32) | 0.22 | 72.5% | ||
| 4 | −0.023 | −0.113 to 0.067 | 0.62 | 2.6 (0.27) | 0.74 | 15.6% | |||
| MAGIC | IVW | 7 | 0.010 | −0.027 to 0.047 | 0.58 | 11.7 (0.07) | 48.7% | ||
| East Asians | WM | 7 | 0.004 | −0.035 to 0.042 | 0.85 | ||||
| MRE | 7 | 0.045 | −0.013 to 0.102 | 0.13 | 8.21 (0.35) | 0.14 | 0% | ||
| Odds Ratio | |||||||||
| Diabetes | DIAMANTE | IVW | 5 | 1.02 | 1.00 to 1.04 | 0.08 | 3.40 (0.49) | 0% | |
| Europeans | 4 | 1.03 | 1.00 to 1.06 | 0.053 | 2.36 (0.50) | 0% | |||
| WM | 5 | 1.02 | 0.99 to 1.04 | 0.18 | |||||
| 4 | 1.03 | 1.00 to 1.07 | 0.06 | ||||||
| MRE | 5 | 1.00 | 0.93 to 1.07 | 0.99 | 3.12 (0.37) | 0.60 | 71.8% | ||
| 4 | 1.17 | 0.93 to 1.47 | 0.18 | 1.15 (0.56) | 0.27 | 22.5% | |||
| Finngen a | IVW | 4 | 0.97 | 0.92 to 1.03 | 0.34 | 2.10 (0.55) | 0% | ||
| Europeans | 3 | 0.96 | 0.89 to 1.03 | 0.27 | 1.72 (0.42) | 0% | |||
| WM | 4 | 0.98 | 0.92 to 1.05 | 0.57 | |||||
| 3 | 0.96 | 0.87 to 1.06 | 0.39 | ||||||
| MRE | 4 | 1.07 | 0.88 to 1.32 | 0.49 | 1.16 (0.56) | 0.33 | 62.3% | ||
| 3 | 1.60 | 0.71 to 3.64 | 0.26 | 0.18 (0,67) | 0.22 | 0% | |||
| AGEN | IVW | 7 | 1.00 | 0.96 to 1.03 | 0.91 | 5.38 (0.50) | 0% | ||
| East Asians | WM | 7 | 0.98 | 0.94, to 1.03 | 0.45 | ||||
| MRE | 7 | 0.97 | 0.92 to 1.03 | 0.32 | 4.01 (0.55) | 0.24 | 0% | ||
| Meta-analysis | Of IVW estimates | 12 | 1.01 | 0.99 to 1.03 | 0.28 | ||||
| 11 | 1.01 | 0.99 to 1.03 | 0.30 | ||||||
a
Rs729876 not available.