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. 2021 Nov 22;13(22):24655–24674. doi: 10.18632/aging.203700

Table 3. Genotypes and haplotype in genetic model analysis.

Variants Case/control Case/control P OR 95%CI
rs687621 Genotype GG AX
Longevity/Control 929/279 4241/5529 2.728*10-107 4.341 3.775-4.992
Nonagenarians/Controls 630/279 2880/5529 2.187*10-95 4.335 3.739-5.026
Centenarians/Controls 299/279 1361/5529 1.441*10-70 4.354 3.660-5.179
Centenarians/Nonagenarians 299/630 1361/2880 0.956 1.004 0.863-1.169
rs643434 Genotype AX GG
Longevity/Control 3572/3173 1982/2635 8.271*10-26 1.497 1.388-1.614
Nonagenarians/Controls 2428/3173 1378/2635 5.134*10-19 1.463 1.345-1.591
Centenarians/Controls 1144/3173 604/2635 5.940*10-14 1.532 1.370-1.713
Centenarians/Nonagenarians 1144/2428 604/1378 0.452 1.047 0.929-1.179
rs505922 Genotype CX TT
Longevity/Control 3579/3182 1973/2626 8.354*10-26 1.497 1.388-1.614
Nonagenarians/Controls 2430/3182 1374/2626 9.168*10-19 1.460 1.342-1.587
Centenarians/Controls 1149/3182 599/2626 4.988*10-16 1.583 1.416-1.770
Centenarians/Nonagenarians 1149/2430 599/1374 0.181 1.085 0.963-1.222
Haplotype of rs8176719, rs687621, rs643434, rs505922 Genotype CGAC/XGXX -AGT/-XGT
Longevity/Control 541/279 4091/4758 2.557*10-27 2.255 1.940-2.621
Nonagenarians/Controls 342/279 2622/4758 3.466*10-22 2.224 1.886-2.624
Centenarians/Controls 199/279 1469/4758 1.458*10-18 2.310 1.908-2.797
Centenarians/Nonagenarians 199/342 1469/2622 0.690 1.039 0.862-1.251

Note: X represents the major allele or minor allele of the corresponding SNP.