Table 3. Genotypes and haplotype in genetic model analysis.
Variants | Case/control | Case/control | P | OR | 95%CI | |
rs687621 | Genotype | GG | AX | |||
Longevity/Control | 929/279 | 4241/5529 | 2.728*10-107 | 4.341 | 3.775-4.992 | |
Nonagenarians/Controls | 630/279 | 2880/5529 | 2.187*10-95 | 4.335 | 3.739-5.026 | |
Centenarians/Controls | 299/279 | 1361/5529 | 1.441*10-70 | 4.354 | 3.660-5.179 | |
Centenarians/Nonagenarians | 299/630 | 1361/2880 | 0.956 | 1.004 | 0.863-1.169 | |
rs643434 | Genotype | AX | GG | |||
Longevity/Control | 3572/3173 | 1982/2635 | 8.271*10-26 | 1.497 | 1.388-1.614 | |
Nonagenarians/Controls | 2428/3173 | 1378/2635 | 5.134*10-19 | 1.463 | 1.345-1.591 | |
Centenarians/Controls | 1144/3173 | 604/2635 | 5.940*10-14 | 1.532 | 1.370-1.713 | |
Centenarians/Nonagenarians | 1144/2428 | 604/1378 | 0.452 | 1.047 | 0.929-1.179 | |
rs505922 | Genotype | CX | TT | |||
Longevity/Control | 3579/3182 | 1973/2626 | 8.354*10-26 | 1.497 | 1.388-1.614 | |
Nonagenarians/Controls | 2430/3182 | 1374/2626 | 9.168*10-19 | 1.460 | 1.342-1.587 | |
Centenarians/Controls | 1149/3182 | 599/2626 | 4.988*10-16 | 1.583 | 1.416-1.770 | |
Centenarians/Nonagenarians | 1149/2430 | 599/1374 | 0.181 | 1.085 | 0.963-1.222 | |
Haplotype of rs8176719, rs687621, rs643434, rs505922 | Genotype | CGAC/XGXX | -AGT/-XGT | |||
Longevity/Control | 541/279 | 4091/4758 | 2.557*10-27 | 2.255 | 1.940-2.621 | |
Nonagenarians/Controls | 342/279 | 2622/4758 | 3.466*10-22 | 2.224 | 1.886-2.624 | |
Centenarians/Controls | 199/279 | 1469/4758 | 1.458*10-18 | 2.310 | 1.908-2.797 | |
Centenarians/Nonagenarians | 199/342 | 1469/2622 | 0.690 | 1.039 | 0.862-1.251 |
Note: X represents the major allele or minor allele of the corresponding SNP.