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editorial

. 2021 Nov 29;13(22):24477–24479. doi: 10.18632/aging.203726

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Copyright: © 2021 Mary and Hippo.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Dynamics of the Kras^G12D-expressing pancreatic cells in the organoid-based carcinogenesis model. Pancreatic organoids from Kras^LSL-G12D/+ mice (black) and Kras^LSL-G12D/+; Trp53^fl/fl mice (red) were lentivirally transduced with Cre. Positive selection for Kras^G12D-expressing cells was observed in a context-dependent manner. ERN(-), organoid culture with culture medium lacking EGF, Rsondin-1, and Noggin; PDA, pancreatic ductal adenocarcinoma; PanIN, pancreatic intraepithelial neoplasia.