TABLE 3.
Positive predictive values of ISTH DIC score for overt DIC, by patient subgroups
| Ratio | PPV, % (95% CI) | Ratio | PPV, % (95% CI) | |
|---|---|---|---|---|
| Age | ≤60 years | >60 years | ||
| 63/89 | 71 (60‐80) | 89/136 | 65 (57‐73) | |
| Sex | Male | Female | ||
| 87/129 | 67 (59‐75) | 65/96 | 68 (57‐77) | |
| Time period | 2015‐2016 | 2017‐2018 | ||
| 79/120 | 66 (57‐74) | 73/105 | 70 (60‐78) | |
| Admission type | ICU | Non‐ICU | ||
| 131/177 | 74 (67‐80) | 21/48 | 44 (30‐59) | |
| DIC etiology | Sepsis | Malignancy | ||
| 96/138 | 70 (61‐77) | 4/10 | 40 (12‐74) | |
| Platelet count | <50 × 109/L | ≥50 × 109/L | ||
| 93/128 | 73 (64‐80) | 59/97 | 61 (50‐71) | |
| Fibrinogen | <2.94 µmol/L | ≥2.94 µmol/L | ||
| 28/33 | 85 (68‐95) | 124/192 | 65 (57‐71) | |
| INR | >1.6 | ≤1.6 | ||
| 131/175 | 75 (68‐81) | 21/50 | 42 (28‐57) | |
| Fibrin D‐dimer | >8.0 mg/L | ≤8.0 mg/L | ||
| 121/173 | 70 (63‐77) | 31/52 | 60 (45‐73) | |
| Antithrombin | ≤0.60 IU/L | >0.60 IU/L | ||
| 104/128 | 81 (73‐88) | 48/97 | 49 (39‐60) | |
| aPTT | >1.5 × upper reference limit a | ≤1.5 × upper reference limit | ||
| 55/64 | 86 (75‐93) | 37/74 | 50 (38‐62) | |
| SOFA score | ≤12 | >12 | ||
| 46/94 | 49 (38–59) | 105/129 | 81 (74–88) | |
Abbreviations: aPTT, activated partial thromboplastin time; CI, confidence interval; DIC disseminated intravascular coagulation; INR, international normalized ratio; PPV, positive predictive value; SOFA, Sequential Organ Failure Assessment.
a
Restricted to individuals after July 1, 2016, due to changes in the reference interval for the analysis.