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. 2021 Dec 9;7:45. doi: 10.1038/s41540-021-00208-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Illustration of our approach to assessing cell-line-specific network relationships through differential network analysis. b ROC curve showing the evaluation of the differential networks that were calculated by comparing the H1HESC and HELAS3 SPIDER seed networks (blue) and regulatory networks (red). c AUC values of each of the pairwise comparisons of the SPIDER seed networks. d AUC values of each of the pairwise comparisons of the SPIDER regulatory networks.