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. 2021 Dec 9;4:1381. doi: 10.1038/s42003-021-02904-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a–c Schematic representations of metabolic responses during (a) and after (b) spaceflight. Vertical arrows denote changes in metabolite levels in the plasma and eWAT during (a) or after (b) spaceflight. Horizontal arrows denote these changes in Nrf2 KO mice. Schematic representations of changes in gene expression in the eWAT, liver and cerebrum after spaceflight are also provided (c). Vertical arrows denote changes in gene expression levels in the eWAT, liver and cerebrum after spaceflight (c). Horizontal arrows denote these changes in Nrf2 KO mice. d Classes of genes in the eWAT, liver and cerebrum. Class 1 includes genes with substantially altered expression in response to spaceflight that are not influenced by the Nrf2 KO genotype; Class 2 includes genes whose expression is affected by Nrf2 KO, but the changes are overridden by spaceflight; and Class 3 includes genes that are modulated by spaceflight, but the changes are overridden by Nrf2 KO.