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. 2021 Dec 9;7:46. doi: 10.1038/s41540-021-00203-8

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Fig. 6 — a p53-wild-type cancer cells. b p53-null cancer cells under the Plk1-depletion condition (Plk1 is depleted by 45% relative to Plk1 level in wild-type cells). The sensitivity intensities are obtained by varying k_s1, k_s8, k_s9, k_s12, k_s13, k_s15, k_s17, k_s20, and k_s33 parameters that control the synthesis rates of Cyclin B, Cdc25, Wee1, Plk1, PP2A, APC/C, Cdc20, Cdh1, and Mad2, correspondingly.