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. 2021 Dec 9;12:7135. doi: 10.1038/s41467-021-27378-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Sample preparation protocol. Control data were also obtained under the same sample preparation and image acquisition conditions on the same day to mitigate potential bias in the image data that may have come from experimental variations in blood draw, sample preparation, optical alignment, and hydrodynamic focusing conditions. See “Sample preparation” in the Methods section for details of the protocol. b Size distribution histograms and typical images of single platelets and platelet aggregates in the blood of mild, moderate, and severe patients with COVID-19. Scale bar: 30 µm. The clinical information and D-dimer level of each patient are also shown in the insets. Control data are also shown as references. P values were obtained using the Wilcoxon rank-sum test (two-sided) and shown in the figure. Source data are provided as a Source Data file.