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. 2021 Dec 9;11:23764. doi: 10.1038/s41598-021-03027-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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NF-YAl is predominant in Claudin^low STAD tumors. (a) Hierarchical clustering of all TCGA tumor samples according to the 24 genes signature described in Ref. ³⁷. (b) Sample repartition in the TCGA (Left Panel) and ACRG (Right Panel) classifications, including the new Claudin^low group identified in (a), before and after the clustering procedure. (c) Box plots of expression levels of NF-YAl (Left Panel), NF-YAs (Central Panel), and NF-YAl/NF-YAs ratio (Right Panel) in the TCGA classification, including the Claudin^low group identified in (a). (d) Same as (c), except that the NF-YA isoforms expression levels are calculated for the ACRG classification subtypes. p values are calculated using the Wilcoxon rank-sum test.