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. 2021 Dec 9;11:23764. doi: 10.1038/s41598-021-03027-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DEG in Claudin^low subtype. (a) List of enriched TFBS in promoters of upregulated and downregulated genes in the Claudin^low subtype, compared to normal tissue, as predicted by Pscan. (b) Heatmap showing the p values, as computed by Pscan, associated to the enrichment in multiple TFBS motifs (columns) of the top 50 most represented GO terms (rows) among upregulated genes in Claudin^low samples, as emerged from the KOBAS analysis. The light blue area highlights NF-Y subunits binding site motifs (CCAAT box). Only terms with less than 500 background genes and TFBS with a significant enrichment in more than 10 terms (p < 0.01) were included in the heatmap.