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. 2021 Dec 9;11:23756. doi: 10.1038/s41598-021-03222-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Receiver operating characteristic (ROC) analysis of serum microRNA (miRNA) level in type 2 diabetes (T2D) with liver cancer cases versus T2D without cancer cases and T2D non-liver cancer cases. The miR-186-5p normalized serum levels of miR-122-5p (@122_exp), miR-455-3p (@455_exp) and miR-4532 (@4532_exp) were analysed using SPSS v.25. The sum of Log values serum level of miR-122-5p and miR-455-3p (122 + 455) and the all-site cancer risk score and the sum of 122 + 455 and all-site cancer risk score (Score adjusted) were included for comparison. The serum levels of T2D liver cancer group were tested against the T2D cancer-free group and T2D with other cancer group combined (A) and the T2D cancer-free group only (B). The diagonal reference line was shown for comparison. The summaries of area under the curve (AUC) with 95% confidence intervals (95% CI), optimal sensitivity and specificity and P values were shown below.