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. 2021 Dec 9;12:7171. doi: 10.1038/s41467-021-27475-2

Fig. 1. The structure of HHIP-N.

Fig. 1

a HHIP domain organisation and construct design. b Cartoon representation of HHIP-N in complex with SOS. In the top panel, the CRD region is depicted in salmon and the N-terminal GAG-binding domain in dark blue. Two disordered loops (DL1 and DL2) are displayed as dashed salmon lines. In the lower panel, the HHIP-N:SOS complex is shown in rainbow colouring (blue: N-terminus, red: C-terminus). The CRD helices are labelled and disulphide bonds are numbered using Roman numerals. c Maps calculated from final HHIP-N model. The 2Fo-Fc map is shown in blue, contoured at 1σ. An anomalous difference map calculated from S-SAD data used for phasing is displayed as a yellow mesh contoured at 4σ. Corresponding disulphide bonds are numbered using Roman numerals. d Structural phylogenetic analysis of CRDs (see Supplementary Table 2).