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. 2021 Dec 9;12:7171. doi: 10.1038/s41467-021-27475-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Cartoon representation of the HHIP-C monomer structure with the β-propeller domain in slate, the EGF repeats in magenta, the GAG-binding sites in yellow and the HhN-binding site in orange. b Arrangement of the two HHIP-C molecules (cartoon representation) around a centrally-coordinated heparin molecule (stick representation). c Close-up view of the boxed region in B, displaying side chain:heparin interactions. Hydrogen bonds are displayed as black dashed lines and sugar residues are numbered using roman numerals (odd, N,O6-disulphoglucosamine; even, O2-Sulphoiduronic acid). d Electrostatic surface potential shown from red (−8 kT/e) to blue (+8 kT/e) with heparin chain shown as sticks. e Comparison of heparin (yellow sticks) and HhN (orange cartoon) interaction sites on HHIP-C electrostatic surface.