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. 2021 Nov 26;9:781365. doi: 10.3389/fcell.2021.781365

FIGURE 1.

FIGURE 1

Positive correlation of expression levels between GSDME gene and EMT markers in human cancer. (A) The protein expression of GSDME and GSDMD was analyzed by Western blot in 30 lung cancer cell lines. (B) Indicated lung cancer cell lines with variable GSDME levels were treated with decitabine (4 μM) at a time course manner and analyzed by Western blot for GSDME and GSDMD protein expression. (C) Indicated lung cancer cell lines with variable GSDME levels were treated with thioguanine (4 μM) at a time course manner and analyzed by Western blot for GSDME and GSDMD protein expression. (D) Hallmark gene sets and gene ontology terms with ssGSEA scores that positively correlated with GSDME transcript expression in CCLE cancer cell lines. (E) The interaction network of hallmark gene sets with ssGSEA scores that positively correlated with GSDME transcript expression in CCLE cancer cell lines. (F) Scatterplots with linear regression line and shaded 95% confidence region for correlation estimation of GSDME transcript expression and EMT ssGSEA scores in CCLE cancer cell lines. R indicated Pearson correlation coefficient. (G) Scatterplots with linear regression line and shaded 95% confidence region for correlation estimation of GSDME transcript expression and EMT ssGSEA scores in CCLE lung cancer cell lines. R indicated Pearson correlation coefficient.