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. 2021 Nov 25;8:763902. doi: 10.3389/fmolb.2021.763902

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Copyright © 2021 Han, Li, Chen and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Analytical workflow of metabolomics studies. A typical metabolomics study includes experimental design, sample collection, sample profiling, data analysis, and functional interpretation stages. Metabolites from biological fluids, cells, and tissues that differ between tumor and control groups can be detected using metabolomics [e.g., nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry (LC-MS), and gas chromatography-mass spectrometry (GC-MS)] and data analyses. Discovery of metabolic biomarkers and pathways that are specific to certain cancers benefit cancer research.