Figure 3.

Depletion of regulatory T cells promotes diabetes development in NOD.ChgA^−/− mice. A and B: Diabetes incidence in female NOD (A) or NOD.ChgA^−/− (B) mice that were either left untreated or treated with two injections of the anti-CD25 antibody (ab) at age 14 and 21 days. Data are from two independent experiments. C: Diabetes incidence in female NOD or NOD.ChgA^−/− mice treated with the anti–PD-1 ab. Mice were given four injections of the anti–PD-1 ab every 3 days and then followed for diabetes. Data are from three independent experiments. P values were calculated by the log-rank (Mantel-Cox) test. **P < 0.01, ****P < 0.0001.