Figure 5.

Pancreas-infiltrating CD8⁺ T cells preferentially recognize the citrullinated GRP78-9X epitope. Pancreas sections from nPOD cases (Supplementary Table 2) were immunohistochemically stained in situ with MMrs loaded with the indicated GRP78 peptides, with a negative control melanocyte MelanA_26–35 peptide, and with positive control UCN3_1–9 and ZnT8_186–194 islet epitopes (low and high reactivity, respectively). A: Representative staining with GRP78-9X MMrs (scale bar 100 µm) and higher magnification of the dotted area (scale bar 33 µm). B–D: Number of MMr⁺ cells/mm² section area of pancreas (B and D) and duodenal mucosa (C). Each point represents an individual case; bars indicate median values. T1D, type 1 diabetes; T2D, type 2 diabetes. *P < 0.05, **P ≤ 0.01 by Mann-Whitney U test.