Western blot analysis of CDK, cyclin, and RB. Western blotting was used to measure levels of CDK2, cyclin E, p-RB (ser780), total RB, ACSL4, and actin. NARF2 pBpuro or K2/D cells were infected with adenoviruses that express CDK2, cyclin E, or an empty vector (CMV) at indicated MOIs and incubated for 48 h before Western blot analysis. A, CDK2 and cyclin E were expressed together. B and C, these proteins were expressed separately in NARF2 pBpuro cells for 48 h before Western blot analysis. CDK, cyclin-dependent kinase; RB, retinoblastoma; MOI, multiplicity of infection.