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CTEN reduced VEGFA expression by binding to c-Cbl and decreasing β-catenin expression. (A) Immunoprecipitation assay showing the interaction of CTEN with CBL. (B) Western blot results showing that CTEN overexpression increased c-Cbl expression and phosphorylation. n = 4. (C) Knockdown of β-catenin by 2 oligos reduced the VEGFA expression. n = 5. **P < .01.
Abbreviations: c-Cbl, casitas B-lineage lymphoma; CTEN, C-terminal tensin-like; VEGFA, vascular endothelial growth factor A.
