Figure 2.

Sarcopenia caused by 1,25(OH)₂D deficiency is related to muscle atrophy. A. Representative micrographs of tibialis anterior muscle sections from 6-month-old WT and Cyp27b1 KO male mice stained with H&E (upper panel) and IF for laminin (bottom panel). B. CSA of myofibers (μm²). C. Mitochondrial-related gene expression levels in 6-month-old WT and Cyp27b1 KO mouse skeletal muscle tissue, including α-S9, Fe-S, COX7α and PGC1α. Values are means ± SEM of 6 determinations per group. **P<0.01; ***P<0.001, compared with WT mice.