Table 2.
Comparison of CSF metabolites in young versus old patients
| Metabolites in CSF | Chemical shift (ppm) | NMR signal integration (mean ± SD) (×10-3 a.u.) | Adjusted fold changea | Adjusted P valuea,# | |
|---|---|---|---|---|---|
|
|
|
|
|||
| Old | Young | Old/Young | Old vs. Young | ||
| Increased metabolite levels in old patients compared to young patients | |||||
| Alanine | 1.455 | 134.7±8.7 | 66.2±12.3 | 2.035 | <0.001* |
| Glycine | 3.556 | 572.3±70.4 | 366.6±98.8 | 1.561 | 0.071 |
| Leucine | 0.998 | 94.1±6.8 | 61.6±9.6 | 1.527 | 0.004* |
| Tyrosine | 6.872 | 33.7±2.7 | 24.0±3.9 | 1.403 | 0.031* |
| Citrate | 2.537 | 1309.4±63.1 | 955.1±89.2 | 1.371 | <0.001* |
| Valine | 1.028 | 78.9±4.1 | 58.0±5.6 | 1.361 | 0.002* |
| Acetate | 1.910 | 145.5±17.4 | 108.4±24.5 | 1.342 | 0.184 |
| Creatinine | 3.037 | 456.1±16.6 | 348.1±23.4 | 1.310 | <0.001* |
| Pyruvate | 2.366 | 244.3±20.6 | 192.6±29.0 | 1.268 | 0.119 |
| Lactate | 4.107 | 7689.8.1±376.8 | 6201.5±531.9 | 1.240 | 0.016* |
| 3-hydroxyisovalerate | 1.193 | 131.8±12.9 | 110.1±18.2 | 1.197 | 0.294 |
| Phenylalanine | 7.410 | 56.9±3.6 | 48.0±5.1 | 1.184 | 0.125 |
| Isoleucine | 0.992 | 24.6±2.3 | 21.6±3.3 | 1.137 | 0.425 |
| 2-hydroxybutyrate | 0.893 | 108.0±17.0 | 107.6±23.9 | 1.003 | 0.989 |
| Glutamine | 2.428 | 1060.2±74.6 | 1059.1±105.4 | 1.001 | 0.992 |
| Decreased metabolite levels in old patients compared to young patients | |||||
| Histidine | 7.722 | 35.6±2.7 | 35.8±3.7 | 0.993 | 0.958 |
| Formate | 8.450 | 19.1±1.4 | 20.4±2.0 | 0.936 | 0.571 |
| Isobutyrate | 1.065 | 32.7±6.8 | 38.9±9.6 | 0.839 | 0.564 |
| Acetone | 2.223 | 78.4±22.1 | 98.1±31.2 | 0.798 | 0.576 |
| Glucose | 5.233 | 1953.3±513.4 | 2528.5±724.8 | 0.773 | 0.483 |
a
P value was adjusted for sex, body mass index (BMI), serum creatinine, and hypertension.
#
P value was calculated using two sample t test.
*
P<0.05.