Table 3.

Comparison of CSF metabolites in middle age patients to young or old patients

Comparison	Young age vs. Middle age		Middle age vs. Old age
Significantly changed metabolites in CSF	Adjusted fold changea	Adjusted P valuea,#	Adjusted fold changea	Adjusted P valuea,#
Alanine	1.179	0.091	1.419	0.041*
Citrate	1.174	0.019*	1.089	0.393
Creatinine	1.165	0.004*	1.152	0.018*
Formate	1.121	0.069	0.816	0.037*
Glucose	0.892	0.389	0.934	0.829
Glycine	1.821	0.057	1.225	0.288
Isoleucine	1.343	0.032*	0.832	0.299
Lactate	1.067	0.258	1.165	0.076
Leucine	1.920	0.001*	1.070	0.605
Tyrosine	1.402	0.013*	1.119	0.397
Valine	1.436	<0.001*	0.966	0.725

^aAdjusted for sex, body mass index (BMI), and hypertension.

^# P value was calculated using two sample t test.

^* P<0.05.