Table 5.

Association of altered CSF metabolites with aging process

Comparison	Young vs. Middle	Middle vs. Old	Young vs. Old
Significantly changed metabolites in CSF	Adjusted ORa,#	Adjusted ORa,#	Adjusted ORa,#
CSF glucose	0.999	0.999	0.999
Alanine	1.014	1.011	1.043*
Citrate	1.002*	1.001	1.009*
Creatinine	1.018*	1.012*	1.032*
Lactate	1.001	1.001	1.006*
Leucine	1.043*	1.012	1.049*
Tyrosine	1.130*	1.036	1.182*
Valine	1.079*	0.989	1.197*
Leucine, Tyrosine	2.950*	2.374	2.794*
Citrate, Valine, Leucine	2.094*	2.219	3.591*
Citrate, Leucine, Tyrosine, Valine	2.371*	2.134	3.571*
Citrate, Lactate, Leucine, Tyrosine, Valine	2.062*	2.717*	3.519*
Alanine, Citrate, Lactate, Leucine, Tyrosine, Valine	2.316	3.125*	3.178*
Alanine, Citrate, Creatinine, Lactate, Leucine, Tyrosine, Valine	2.319*	2.933	2.858*

Abbreviation: OR, odds ratio.

^aAdjusted for age, sex, body mass index (BMI), and hypertension.

^#Odds ratio was calculated using logistic regression model.

^* P<0.05.