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. 2021 Nov 24;36(1):307. doi: 10.4102/sajid.v36i1.307

TABLE 1.

Gyssen’s algorithms for evaluation of the appropriateness of antimicrobial drug therapy.

Category Reason categorisation
I Agree with the use of antimicrobial therapy/ prophylaxis, the prescription is definitely appropriate
II The antimicrobial drug therapy/prophylaxis prescription is inappropriate due to:
IIa 1. improper dosage
IIb 2. improper dosage interval
IIc 3. improper route
III The antimicrobial drug therapy/prophylaxis prescription is inappropriate due to:
IIIa 1. excessive length
IIIb 2. duration too short
IV The antimicrobial drug therapy/prophylaxis prescription is inappropriate due to:
IVa 1. more effective alternative agent (Aa): specify
IVb 2. less toxic Aa: specify
IVc 3. less expensive Aa: specify
IVd 4. less broad spectrum Aa: specify
V The antimicrobial drug therapy/prophylaxis prescription is unjustified: use of any antimicrobial is not indicated
VI Records insufficient for categorisation.

Gyssens IC, Van Den Broek PJ, Kullberg B-J, Hekster YA, Van Der Meer JW. Optimizing antimicrobial therapy. A method for antimicrobial drug use and evaluation. J Antimicrob Chemother. 1992;30(5):724–727. https://doi.org/10.1093/jac/30.5.724