Table 3.
Proposal of a Response Pattern Classification at 6 months
| Pattern | Volume Response Undertreatment | Pretreatment GR Range | Undertreatment GR Range |
Clinical Impact |
|---|---|---|---|---|
| 1 | Decrease | ≥+10%/ 6 months |
Volume decrease ≥ –25%/6 months |
Clinical benefit |
| 2A | Stabilization | ≥+10%/6 months | Volume decrease ≤–25%/6 months and GR ≤ +10%/6 months |
Clinical benefit |
| 2B | Slight increase with GR slowdown |
>+30%/6 months | +10% ≤ GR ≤ +30%/6 months | Likely clinical benefit |
| 3A | Persistent slight increase | ≥+10%/6 months <+30%/6 months |
≥+10%/6 months <+30%/6 months |
No or modest clinical interest |
| 3B | Persistent high increase | ≥+30%/6 months | >+30%/6 months | No or modest clinical interest |
Abbreviation: GR, growth rate.