Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 26;12:719758. doi: 10.3389/fphar.2021.719758

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Zhang, Huang, Qiu, Wu, Xin, Cai, Shang, Lin, Zhang, Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The process of SARS-CoV2 virus infection of host cells. Note: The replication cycle of SARS-CoV2 in virus-susceptible host cells: (1) ACE2 binds to the RBD of the spike protein (S) and then fuses with the host cell membrane. (2) Release the positive single-stranded RNA. (3, 4) Partially translate into SARS-CoV2 polymerase protein. (5) Transcribe. (6) The resulting subgenomic RNA translated S, M, and E proteins are transported to the ER membrane of the host cell and then bind to the nucleocapsid protein (N). (7) To-after processing in the Golgi apparatus. (8) Mature virus particles are formed and transported to the cell membrane. (10) New SARS-CoV2 particles are excreted by exocytosis (9).