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. 2021 Dec 8;41(12):BSR20211191. doi: 10.1042/BSR20211191

Figure 6. In NSCs derived from iPSCs of schizophrenic patients mt-HK is unable to modulate mitochondrial ROS.

Figure 6

(A) Representative experiments of flow cytometry for MitoSOX Red fluorescence with (red) or without (black) 2-DOG 35 mM in NSCs derived from healthy individuals or schizophrenic patients-iPSCs. The gray area corresponds to the negative control (without MitoSOX Red). (B) Quantification of MitoSOX Red fluorescence in response to 2-DOG 35 mM by control and schizophrenic-derived NSCs (n = 3 per group). The basal ROS was plotted as 100% and the fluorescence of MitoSOX Red after 2-DOG was normalized by the basal ROS (without 2-DOG). The differences between groups were analyzed by unpaired t-test with Welches correction in b (n = 3 per group); Veh, vehicle.