Table 3. Summary of the motor features seen in animal models of PD.
Model | Motor deficits | Responds to L-DOPA | Develops L-DOPA-induced dyskinesias |
---|---|---|---|
MPTP | ✓ | ✓ | ✓ |
6-OHDA | ✓ | ✓ | ✓ |
LPS | ✓ | ND | ND |
Rotenone | ✓ | ✓ | ✓ |
Paraquat | ✓ | ✓ | ND |
Permethrin | ✓ | ✓ | ND |
Reserpine | ✓ | ✓ | ND |
Haloperidol | ✓ | ND | ND |
AAV | ✓ | Inconclusive | ND |
PFF | ✓ | ND | ND |
Transgenic | |||
SNCA | Inconclusive | ND | ND |
LRRK2 | ✓ | ✓ | ND |
GBA | ✗ | n/a | ND |
Ticks indicate features reportedly seen in a model, while cross indicates features demonstrated as absent. ND, not documented; Inconclusive, literature shows evidence for and against this feature in the model; n/a, not applicable, due to the lack of motor deficits. For relevant references, please see the main text.