Table 4. Summary the non-motor features seen in animal models of PD.

Model	Sensory abnormalities	Somnolescent alterations	Cognitive deficits	Psychiatric changes	Organ system dysfunction
MPTP	✓	✓	✓	✓	✓
6-OHDA	✓	✓	✓	✓	✓
LPS	ND	ND	✓	✓	✓
Rotenone	✓	✓	✓	✓	✓
Paraquat	✓	ND	✓	✓	✓
Permethrin	ND	ND	✓	✓	✓
Reserpine	✓	ND	✓	✓	ND
Haloperidol	✗	ND	ND	ND	ND
AAV	✓	ND	ND	✓	ND
PFF	✓	✓	✓	✓	✓
Transgenic
SNCA	✓	✓	✓	✗	✓
LRRK2	✓	✓	✓	Inconclusive	✓
GBA	✗	ND	✓	ND	✗

Ticks indicate features reportedly seen in a model, while crosses indicate features demonstrated as absent. ND, not documented; Inconclusive, literature shows evidence for and against this feature in the model. For relevant references, please see the main text.