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. 2021 Nov 26;9:783456. doi: 10.3389/fcell.2021.783456

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Copyright © 2021 Li, Li, Liu, Lv, Wang, Gao, Zhang, Jiang, Chai, Yun, Tan, Gong, Wu, Zhu, Ma and Leng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Matrisome profile of the human skin dermis. (A) General workflow of the whole experimental design, including decellularization, mass spectrometry-based quantitative proteomics, bioinformatics analyses, and experimental verification. (B) Six types of ECM proteins (collagens, ECM glycoproteins, proteoglycans, ECM regulators, ECM-affiliated proteins, and secreted factors) expressed at four ages (toddler, teenager, adult, and elderly). Pie charts represent the proportion of the six components (collagens, ECM glycoproteins, proteoglycans, ECM regulators, ECM-affiliated proteins, and secreted factors) that make up the matrisome in the human skin dermis. (C) Overlap of ECM proteins in the skin scaffolds of four ages (toddler, teenager, adult, and elderly). (D) Histogram shows the number of the six ECM components identified at four age stages. (E) PCoA analysis of the samples at four ages (toddler, teenager, adult, and elderly) based on their ECM profile. The technical repeats were produced for each sample, represented by different colored points in the figure.