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. 2021 Nov 26;9:783456. doi: 10.3389/fcell.2021.783456

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Copyright © 2021 Li, Li, Liu, Lv, Wang, Gao, Zhang, Jiang, Chai, Yun, Tan, Gong, Wu, Zhu, Ma and Leng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Coexpression analysis of age-specific ECM protein modules. (A) Four protein modules revealed ECM specificity based on age stage. Cluster 1−4 are the protein groups highly expressed in toddler, teenager, adult and elderly, respectively. (B) Heatmap analysis of ECM identified in samples from skin bioscaffolds of four ages (toddler, teenager, adult, and elderly) according to log₂ normalized protein intensity. Red and blue boxes indicate proteins with increased and decreased abundance, respectively. Green, purple, and rose bars correspond to the proteins enriched in skin bioscaffolds from toddler, teenager, adult, and elderly. (C) Clusters of proteins associated with similar biological process were grouped according to the degree of enrichment.