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Highly expressed proteins of the six ECM components in the human skin dermis at four ages (toddler, teenager, adult, and elderly). (A–F) Histograms show highly expressed proteins of the collagen ECM, proteoglycan ECM, ECM glycoprotein, ECM-affiliated protein, secreted factor ECM, and ECM regulator, respectively. (G) Immunohistochemistry of ANXA5 and MMP2 in the skin tissues of toddler, teenager, adult, and elderly (scale bar represents 50 μm).
