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. 2021 Nov 26;9:783456. doi: 10.3389/fcell.2021.783456

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Copyright © 2021 Li, Li, Liu, Lv, Wang, Gao, Zhang, Jiang, Chai, Yun, Tan, Gong, Wu, Zhu, Ma and Leng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Roles of ECM proteins in human dermal development. (A) Upregulated and downregulated ECM proteins in the human skin dermis at four ages (toddler, teenager, adult, and elderly). Each circle represents an age stage. Blue, pink, yellow, purple, green, and cyan lines correspond to the six components (collagens, ECM glycoproteins, proteoglycans, ECM regulators, ECM-affiliated proteins, and secreted factors) of the skin ECM. (B) Schematic representation of dermal ECM function evolution during human skin development and aging. (C) Expression of COL6A1, COL12A1, and SLPI in skin scaffolds of four ages (toddler, teenager, adult, and elderly). (D) Immunofluorescence of SLPI, COL6A1, and COL12A1 identified in the human skin dermis (scale bar represents 50 μm).