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. 2021 Nov 26;8:759273. doi: 10.3389/fmed.2021.759273

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Copyright © 2021 Xu, Li, Gao, Shang, Zhang, Mao, Chen, Zheng, Shan, Chen, Xie and Hao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receiver Operating Characteristics (ROC) curve in both cohorts. The areas under ROC (AUC) of serum TNC, SOFA, APACHE II, and SAPS II for predicting all-cause mortality were 0.803, 0.808, 0.762, and 0.779 (p < 0.001 for all) in the emergency (derivation) cohort and 0.745, 0.844, 0.846, and 0.872 (p < 0.001) in the inpatient (validation) cohort. In the emergency cohort, there was no significant difference between serum TNC and the three critical illness scores. In the inpatient cohort, the AUC of serum TNC was significantly lower than SAPS II (p = 0.032) while there was no significant difference between serum TNC and SOFA or APACHE II.