Table 2.
Multivariate analysis for risk factors of all-cause mortality in patients with multiple organ dysfunction.
| Variables | Emergency (derivation) cohort | Inpatient (validation) cohort | ||
|---|---|---|---|---|
| Adjusted OR (95% CI) | p-value | Adjusted OR (95% CI) | p-value | |
| Model 1 | ||||
| Age | 0.980 (0.950, 1.010) | 0.191 | 1.012 (0.985, 1.040) | 0.377 |
| Gender | 1.341 (0.474, 3.794) | 0.581 | 0.604 (0.219, 1.668) | 0.331 |
| Sepsis | 1.255 (0.433, 3.635) | 0.676 | 1.718 (0.576, 5.121) | 0.332 |
| TNC (per 100 ng/ml increase) | 1.656 (1.288, 2.130) | <0.001 | 1.261 (1.084, 1.467) | 0.004 |
| Model 2 | ||||
| Age | 0.979 (0.946, 1.013) | 0.215 | 1.014 (0.986, 1.042) | 0.341 |
| Gender | 1.475 (0.469, 4.634) | 0.505 | 0.651 (0.214, 1.978) | 0.449 |
| SOFA | 1.423 (1.181, 1.715) | <0.001 | 1.275 (1.088, 1.495) | 0.003 |
| TNC (per 100 ng/ml increase) | 1.678 (1.276, 2.206) | <0.001 | 1.137 (1.024, 1.262) | 0.016 |
| Model 3 | ||||
| Age | 0.976 (0.945, 1.009) | 0.150 | 1.007 (0.980, 1.035) | 0.629 |
| Gender | 1.516 (0.496, 4.638) | 0.466 | 0.761 (0.262, 2.210) | 0.616 |
| APACHE II | 1.142 (1.053, 1.239) | 0.001 | 1.138 (1.034, 1.253) | 0.008 |
| TNC (per 100 ng/ml increase) | 1.630 (1.276, 2.083) | <0.001 | 1.118 (1.011, 1.237) | 0.030 |
| Model 4 | ||||
| Age | 0.969 (0.936, 1.002) | 0.558 | 0.993 (0.962, 1.025) | 0.663 |
| Gender | 1.429 (0.468, 4.363) | 0.556 | 0.653 (0.217, 1.964) | 0.449 |
| SAPS II | 1.076 (1.031, 1.123) | 0.001 | 1.092 (1.032, 1.157) | 0.002 |
| TNC (per 100 ng/ml increase) | 1.524 (1.203, 1.930) | <0.001 | 1.109 (0.997, 1.234) | 0.057 |
TNC, tenascin-C; SOFA, Sequential Organ Failure Assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; SAPS II, Simplified Acute Physiology Score II.