Table 3.
Comparisons between patients with serum TNC ≥ 300 ng/ml and serum TNC < 300 ng/ml.
| Emergency (derivation) cohort | Inpatient (validation) cohort | |||||
|---|---|---|---|---|---|---|
| TNC < 300 ng/ml | TNC ≥ 300 ng/ml | P | TNC < 300 ng/ml | TNC ≥ 300 ng/ml | P | |
| n = 65 | n = 45 | n = 71 | n = 44 | |||
| Age (years) | 61 (48, 71) | 67 (60, 78) | 0.002 | 51 (35, 62) | 64 (49, 74) | 0.001 |
| Male, n (%) | 46 (70.8%) | 28 (62.2%) | 0.350 | 42 (59.2%) | 33 (75.0%) | 0.084 |
| Creatinine (mg/dL) | 0.8 (0.6, 1.5) | 1.3 (0.7, 3.2) | 0.043 | 1.9 (0.7, 5.0) | 4.5 (2.4, 7.8) | 0.001 |
| CRP (mg/L) | 42 (7, 169) | 135 (32, 200) | 0.023 | 11 (3, 23) | 81 (10, 135) | 0.002 |
| D-dimer (μg/mL) | 3.4 (1.4, 4.6) | 5.6 (2.6, 11.1) | 0.002 | 1.5 (0.5, 2.8) | 4.6 (2.3, 12.6) | <0.001 |
| Sepsis, n (%) | 25 (38.5%) | 36 (80.0%) | <0.001 | 11 (15.5%) | 20 (45.5%) | <0.001 |
| SOFA | 4.0 (3.0, 7.5) | 7.0 (6.0, 8.5) | 0.003 | 5.0 (3.0, 8.0) | 7.0 (5.0, 9.0) | 0.001 |
| APACHE II | 14.0 (10.0, 18.0) | 18.0 (14.0, 22.5) | 0.003 | 11.0 (7.0, 16.0) | 17.0 (15.0, 22.0) | <0.001 |
| SAPS II | 38.0 (31.0, 49.8) | 47.0 (41.5, 62.0) | <0.001 | 33.0 (26.0, 41.0) | 41.5 (35.5, 53.0) | <0.001 |
| Mortality, n (%) | 9 (13.8%) | 26 (57.8%) | <0.001 | 10 (14.1%) | 17 (38.6%) | 0.003 |
TNC, tenascin-C; CRP, C-reactive protein; SOFA, Sequential Organ Failure Assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; SAPS II, Simplified Acute Physiology Score II.