Fig. 8.

Therapeutic effects of adenoviral (Ad)-mediated RND3 overexpression on hypertension and vascular remodeling. The rat in WKY or SHR group was subjected to intravenous administration of PBS, Ad-scrambled RND3 (NC) or Ad-RND3 (RND3 OE, 1 × 10⁷ plaque forming units). The blood pressure was measured every week in awake state. The vascular remodeling was examined 4 weeks after the intravenous injection. A, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) in WKY and SHR. B, bar graph showing the Masson's staining analysis for media thickness, lumen diameter and the ratio of medium thickness to lumen diameter in aorta and mesentery artery (MA). C, representative images of Masson's staining of aorta and MA. D, bar graph showing the relative values of the PCNA immunohistochemistry analyses. E, representative images of PCNA immunohistochemistry (brown color) in aorta and mesentery artery (MA). Values are mean ± SE. *P < 0.05 vs WKY; †P < 0.05 vs. PBS or NC. n = 6 per group. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)