TABLE 2.
Sociodemographic and clinical characteristics associated with time to first negative test among immunocompromised children with two consecutive negative tests (n = 61)
| Total (n = 61)N (%) | Time to first negative <30 days (n = 30)N (%) | Time to first negative >30 days (n = 31)N (%) | p‐Value | |
|---|---|---|---|---|
| Age ≤10 years | 20 (33) | 9 (30) | 11 (35) | .65 |
| Immunocompromising condition | ||||
| Oncology ‐ solid tumor | 10 (16) | 6 (20) | 4 (13) | .33 |
| Oncology ‐ leukemia/lymphoma | 31 (51) | 12 (40) | 19 (61) | |
| HSCT | 4 (7) | 3 (10) | 1 (3) | |
| Bone marrow failure syndrome | 2 (3) | 2 (7) | 0 (0) | |
| Solid organ transplant | 1 (2) | 1 (3) | 0 (0) | |
| HIV | 1 (2) | 0 (0) | 1 (3) | |
| Other | 11 (18) | 6 (20) | 5 (16) | |
| Asymptomatic at the time of initial positive test | 35 (57) | 20 (67) | 15 (48) | .15 |
| Immunosuppression based on ANC | .15 | |||
| High level | 16 (34) | 11 (48) | 5 (21) | |
| Low level | 10 (21) | 4 (17) | 6 (25) | |
| No immunosuppression | 21 (45) | 8 (35) | 13 (54) | |
| Immunosuppression based on ALC | ||||
| High level | 25 (54) | 11 (48) | 14 (61) | .65 |
| Low level | 11 (24) | 6 (26) | 5 (22) | |
| No immunosuppression | 10 (22) | 6 (26) | 4 (17) | |
| Steroids | 15 (25) | 6 (20) | 9 (29) | .41 |
| Chemotherapy medication | 41 (67) | 18 (60) | 23 (74) | .24 |
Abbreviations: ALC, absolute lymphocyte count; ANC, absolute neutrophil count; HIV, human immunodeficiency virus; HSCT, hematopoietic stem cell transplant.
a
Pearson's chi‐square test.
b
Steroid dose consistent with immunosuppression.