TABLE 1.

Cell densities and mRNA yields

Time pointa	Strain	Cell density (cells/ml) at:			mRNA (μg)
		Introduction of drug	Harvest		Control cultures	Treated cultures
			Control cultures	Treated cultures
Early	499	4.3 × 106	1.7 × 107	1.1 × 107	9.9	14.7
	1052	4.5 × 106	1.5 × 107	8.2 × 106	25.5	13.3
Middle	499	4.2 × 106	3.2 × 107	1.4 × 107	6.6	14.4
	1052	4.1 × 106	4.2 × 107	1.1 × 107	8.0	15.4
Late	499	3.0 × 106	3.5 × 107	2.6 × 107	13.1	6.4
	1052	3.2 × 106	3.2 × 107	1.8 × 107	9.4	7.5

^aEarly, 2 h; middle, 3 h; late, 4.5 h. Treated cultures received 1.5, 2.5, and 2.5 mg/ml for the early, middle and late time points, respectively.