TABLE 1.

Anti‐HCV activities of quercetin and derivates

Compound	Mechanism	References
Quercetin	Reduces HSP70 and NS5A levels demonstrating its effect on IRES translation	Khachatoorian et al. (2012)
Quercetin	Inhibits the cleavage of the engineered NS3	Bachmetov et al. (2012)
Quercetin	Inhibits HCV‐induced ROS and RNS formation in HCV‐replicating cells through its antioxidant activity	Pisonero‐Vaquero et al. (2014)
Quercetin‐7‐O‐arylmethylquercetins Quercetin‐3‐O‐benzoic acid esters	Compounds are capable of establish key coordination with the two magnesium ions as well as interactions with residues at the active site of HCV NS5B	Zhong et al. (2015)
Quercetin	Docking results provide that Que is a potent inhibitor of NS2 protease of HCV	Sajitha Lulu et al. (2016)

Note: HCV, hepatitis C virus; HSP70, heat shock protein 70; IRES, internal ribosome entry site; Que, Quercetin; RNS, reactive nitrogen species; ROS, reactive oxygen species.