TABLE 2.
Anti Herpesviridae activities of quercetin and derivates
| Compound | Mechanism | References |
|---|---|---|
| Quercetin | Inhibits production of IEG and IEP with IC50 145 μM for HSV and 2.89 μM for HCMV | Cotin et al. (2012) |
| Quercetin Isoquercetin | Inhibits HSV entry and inhibit NF‐κB activation | Hung et al. (2015) |
| Quercetin | Suppresses the activations of IRF3 and NF‐jB induced by HSV‐1 infection in a TLR3‐dependent manner, and this resulted in reduced TNF‐α production in raw 264.7 cells | Lee et al. (2017) |
| Quercetin | Counteracts EBV‐driven immortalization of B cells and LCL outgrowth. This effect seems to occur interrupting the crosstalk between IL‐6 and STAT3, promoted autophagy, and reduced ROS levels and p62 accumulation | Granato et al. (2019) |
| Quercetin | Inhibit viral lytic gene expression and replication through the downregulation of IEG of VZV and HCMV (IE2) | Kim et al. (2020) |
| Isoquercetin |
Note: EBV, Epstein–Barr virus; IC50, half‐maximal inhibitory concentration; IEG, immediate early genes; IEP, immediate early protein; HCMV, human cytomegalovirus; HSV‐1, Herpes Simplex Virus type‐1; IL‐6, interleukin‐6 virus; LCL, lymphoblastoid cell line; TLR, toll‐like receptor, TNF, tumor necrosis factor; VZV, Varicella Zoster virus.