. 2021 Oct 28;36(1):266–278. doi: 10.1002/ptr.7309

TABLE 6.

Anti‐HIV activities of quercetin and derivates

Compound	Mechanism	References
Quercetin	Strong inhibitory activity on HIV‐1 IN with IC₅₀ 11.0 μM and TOP2, IC₅₀ 19.4 μM	Fesen et al. (1993)
Quercetin‐3‐O‐β‐d‐glucopyranoside; Quercetin‐3‐O‐β‐d‐galactopyranoside	Compounds inhibit HIV‐1 IN with IC₅₀ 19.4 and 21.8 μM, respectively	Chaniad et al.( 2016)
Quercetin	Reactivates latent HIV‐1 gene expression and induces nuclear factor κB nuclear translocation	Yang et al. (2018)

Compound

Mechanism

References

Quercetin

Strong inhibitory activity on HIV‐1 IN with IC₅₀ 11.0 μM and TOP2, IC₅₀ 19.4 μM

Fesen et al. (1993)

Quercetin‐3‐O‐β‐d‐glucopyranoside;

Quercetin‐3‐O‐β‐d‐galactopyranoside

Compounds inhibit HIV‐1 IN with IC₅₀ 19.4 and 21.8 μM, respectively

Chaniad et al.( 2016)

Quercetin

Reactivates latent HIV‐1 gene expression and induces nuclear factor κB nuclear translocation

Yang et al. (2018)

Note: HIV‐1, human immunodeficiency virus type 1; IC50, half‐maximal inhibitory concentration; IN, integrase; TOP2, topoisomerase 2.