TABLE 7.

Anti picornavirus activities of quercetin and derivates

Compound	Mechanism	References
Quercetin	Inhibits viral infection at multiple stages, including endocytosis, transcription of the viral genome and viral protein synthesis.	Ganesan et al.(2012)
Dihydroquercetin	Shows antiviral properties against CVB4	Galochkina et al. (2016)
Quercetin	Inhibits EV71 replication in RD cells with IC50 12.1 μM and Vero cells with IC50 8.8 μM. Moreover, Que acts inhibiting 3Cpro with IC50 30.3 μM.	Yao et al. (2018)

Note: 3Cpro, 3C protease; CVA16, coxsackievirus A16; EV71, Enterovirus 71; CVB4, coxsackievirus B4; IC₅₀, half‐maximal inhibitory concentration; RD cells, rhabdomyosarcoma cells; Que, Quercetin.