TABLE 8.

Anti Pneumoviridae activities of quercetin and derivates

Compound	Mechanisms	References
Quercetin	Protects cells form MPV infection and reduces cytokine and chemokine secretion.	Komaravelli et al. (2015)
Quercetin	Interacts with NS1 protein, the enthalpy and entropy balanced forces indicated that the NS1‐quercetin interaction presented both hydrophobic and electrostatic contributions.	Gomes et al. (2016)
Quercetin	Interacts with M2‐1 protein and that hydrogen bonds and stacking interactions are important contributions for stabilization of the complexes.	Guimarães et al. (2018); Teixeira et al. (2017)
Quercetin and acetylated derivatives	Acetylated derivatives protect HEp‐2 cells infected with RSV and interact with F‐protein showing ΔG = −14.22 kcal/mol	Lopes et al. (2020)

Note: HEp‐2 cells, human epithelial type 2 cells; MPV, metapneumovirus; NS1, nonstructural protein 1; RSV, respiratory syncytial virus.